Impact of Tumor Oxygenation on Drug Resistance Evolution under Hypoxia-activated Prodrug Therapy
نویسندگان
چکیده
Hypoxia-activated prodrugs (HAPs) have been designed to target low-oxygen regions within tumors, where drug-resistant clones may thrive. We demonstrated in previous mathematical modeling work that, when combined with standard tyrosine kinase inhibitor therapy, they may have the potential to significantly improve treatment outcomes for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Here, we extend this work to investigate how varying tumor oxygenation may be used to alter response to the combination therapy. Our framework can be used to develop optimal therapeutic regimens that may further reduce tumor burden and probability of resistance in patients with NSCLC.
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